Place chicken breasts into the bottom of a 6-quart crock pot.
Sprinkle chili powder, cumin, paprika, onion powder, garlic powder, black pepper, salt, and dried oregano over the chicken.
Pour salsa over the seasoned chicken. Stir gently to combine all ingredients.
Cover and cook on LOW for 4 hours or on HIGH for 2 hours, or until the chicken shreds easily with two forks.
Once cooked, shred the chicken directly in the crock pot, allowing it to soak up the flavorful cooking liquid.
Serve the shredded salsa chicken in tacos, burritos, bowls, or over rice.